PROVO, Utah and MOUNTAIN VIEW, Calif., March 17, 2015 — DNAnexus, a pioneer in cloud-based genome informatics and data management, and Tute Genomics, a leading genome annotation and interpretation platform, today announced an integrated solution for genomic data management. Customers will be able to access the Tute platform and DNAnexus pipelines from either company’s cloud environment.
DNAnexus provides an enterprise-level solution that combines cloud computing with advanced bioinformatics to power genomic analysis tools. Tute Genomics specializes in genome analysis, creating meaningful reports of an individual’s full genomic profile that researchers/clinicians can interpret, or performing association analysis to gain critical insights into the molecular basis of diseases. The collaboration between the two companies allows Tute Genomics to provide its customers with an end-to-end solution, where a clinical researcher can take raw sequence data through genome interpretation in a single step.
“The DNAnexus platform is becoming the go-to solution for data interpretation tool providers who are seeking a secure, compliant and scalable platform on which they can deploy and expand their product portfolios,” said Richard Daly, CEO of DNAnexus. “We are proud of the collaboration with Tute Genomics, which has enabled our mutual customers to move seamlessly between the two environments in a powerful new end-to-end analytical solution for genomic biomarker discovery and interpretation.”
Reid Robison, CEO of Tute Genomics, commented on the DNAnexus partnership: “We have a passion to enable precision medicine in fast and affordable manner through genome sequencing. The integration with DNAnexus brings expertise from both companies together to offer an integrated, end-to-end solution for both research and clinical users, accelerating the pace of scientific discoveries and enabling the implementation of personalized medicine.”
Clinical researchers can now easily perform best practice data analysis and bring the world’s scientific literature together without the hassle of connecting multiple systems, transferring large files or deploying costly local solutions. Web-based tools allow labs or their sequencing providers to upload raw sequence data files directly onto DNAnexus, where these data will be automatically processed through proprietary pipelines developed by Tute to generate “VCF” data files that can be analyzed using Tute’s genome interpretation solutions.
“Tute and DNAnexus share a common vision to make genomics more accessible to healthcare providers, scientific researchers and even consumers, in order to advance individualized, genome-guided medicine,” said Dr. Kai Wang, President and Co-Founder of Tute Genomics. “Through our collaboration with DNAnexus, we can now offer Tute customers upstream primary analyses and downstream interpretations in a seamless fashion, which will ultimately help make medical intervention and care decisions easily and rapidly.”
Juneau Biosciences, which focuses on the diagnosis and treatment of common women’s health conditions, is an early adopter of this new integrated pipeline. Juneau uses the Tute platform for endometriosis biomarker discovery. Prior to an integrated pipeline with DNAnexus, Juneau performed variant calling and alignment in-house, and then manually transferred variant files to Tute for annotation and analysis. As the project scaled, their local pipeline became computationally taxing and unsustainable. The cloud offers near-infinite scalability, and the new integrated pipeline allows Juneau’s data to flow seamlessly from next-generation sequencer, through variant calling and alignment in the DNAnexus environment, to discovery and interpretation in the Tute platform.
Dr. Ken Ward, Founder and CEO of Juneau Biosciences shared that: “The integration of Tute with DNAnexus greatly expands Juneau’s bioinformatics capability and provides a scalable solution as we continue to grow. This cloud-based solution is saving Juneau hundreds of thousands of dollars that we would have to spend on our own in-house hardware and programming.”
As part of this collaboration, DNAnexus has created an export tool, available to customers via the DNAnexus App Library, which enables customers to securely transfer genome variants data into the Tute Genomics solution for downstream analysis, including annotation, interpretation and clinical reporting. Similarly, Tute has created a data uploader, where users of the Tute platform can directly upload FASTQ files from next-generation sequencers, generate variant calls, annotate the genetic variant data, perform association analysis and interactively draft clinical reports on the Tute platform.
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View original press release here.
Also featured on GenomeWeb, Front Line Genomics.